Kodi Ndi ChiyaniResveratrol?
Resveratrol ndi mankhwala achilengedwe omwe amapezeka muzomera zina, zipatso, ndi vinyo wofiira. Ndi gulu la mankhwala otchedwa polyphenols, omwe amakhala ngati antioxidants ndipo amadziwika chifukwa cha ubwino wawo wathanzi. Resveratrol imakhala yochuluka kwambiri pakhungu la mphesa zofiira ndipo yakhala nkhani ya maphunziro ambiri chifukwa cha zotsatira zake pazochitika zosiyanasiyana za thanzi.
Kafukufuku wina akuwonetsa kuti resveratrol ikhoza kukhala ndi phindu paumoyo wamtima, chifukwa imathandizira kuthandizira mitsempha yamagazi ndikuyenda bwino. Kuphatikiza apo, adaphunziridwa chifukwa cha anti-yotupa komanso antioxidant katundu, zomwe zitha kukhala ndi tanthauzo paumoyo wonse komanso ukalamba.
Resveratrol yafufuzidwanso chifukwa cha gawo lake lothandizira thanzi laubongo ndi chidziwitso, komanso zotsatira zake pa metabolism ndi phindu lomwe lingakhalepo pakuwongolera kulemera.
Zakuthupi ndi Zamankhwala za Resveratrol
Resveratrol (3-4'-5-trihydroxystilbene) ndi non-flavonoid polyphenol pawiri. Dzina lake la mankhwala ndi 3,4',5-trihydroxy-1,2-diphenylethylene (3,4',5-trihydroxystilbene), mawonekedwe ake a molekyulu ndi C14H12O3, ndipo kulemera kwake kwa maselo ndi 228.25.
Resveratrol yoyera imawoneka ngati ufa wonyezimira wonyezimira, wopanda fungo, wosasungunuka m'madzi, komanso wosungunuka mosavuta mu zosungunulira za organic monga ether, chloroform, methanol, ethanol, acetone, ndi ethyl acetate. Malo osungunuka ndi 253-255 ° C, ndipo kutentha kwa sublimation ndi 261 ° C. Ikhoza kufiira ndi njira za alkaline monga madzi ammonia, ndipo imatha kuchitapo kanthu ndi ferric chloride-potassium ferrocyanide. Katunduyu angagwiritsidwe ntchito kuzindikira resveratrol.
Natural resveratrol ili ndi magawo awiri, cis ndi trans. Zimapezeka makamaka mu trans conformation mu chilengedwe. Mapangidwe awiriwa amatha kuphatikizidwa ndi shuga kuti apange cis ndi trans resveratrol glycosides. Cis- ndi trans-resveratrol glycosides amatha kumasula resveratrol pansi pa zochita za glycosidase m'matumbo. Pansi pa kuwala kwa ultraviolet, trans-resveratrol imatha kusinthidwa kukhala cis-isomers.
Njira Yokonzekera
Natural zomera m'zigawo njira
Mphesa, knotweed ndi mtedza amagwiritsidwa ntchito ngati zopangira kuti atulutse ndi kulekanitsa resveratrol yaiwisi, ndikuyiyeretsa. Tekinoloje yayikulu yochotsa zinthu monga organic zosungunulira m'zigawo, m'zigawo zamchere ndi m'zigawo za enzyme. Njira zatsopano monga microwave-assisted m'zigawo, CO2 supercritical m'zigawo ndi akupanga-anathandiza m'zigawo amagwiritsidwanso ntchito. Cholinga cha kuyeretsedwa makamaka ndikulekanitsa ma cis- ndi ma trans-isomers a resveratrol ndi resveratrol kuchokera ku resveratrol yacrude kuti apeze trans-resveratrol. Njira zoyeretsera zodziwika bwino ndi monga chromatography, silica gel column chromatography, thin layer chromatography, high performance liquid chromatography, etc.
Synthesis njira
Popeza ziliresveratrolmu zomera ndi otsika kwambiri ndipo mtengo m'zigawo ndi mkulu, ntchito mankhwala, zamoyo, majini engineering ndi njira zina kupeza resveratrol wakhala njira yofunika kwambiri pa chitukuko chake. Perkin reaction, Hech reaction, ndi Witting-Hormer reaction ndi njira zokhwima zamakina zopangira resveratrol, zokolola za 55.2%, 70%, ndi 35.7% motsatana. Ukadaulo waukadaulo wama genetic umagwiritsidwa ntchito kuwongolera kapena kukonza njira ya biosynthesis ya resveratrol kuti ipeze zokolola zambiri za mbewu; njira monga kugwiritsa ntchito mutagenesis kuti musankhe mizere ya maselo olemera kwambiri amatha kuwonjezera zokolola za resveratrol ndi 1.5 ~ 3.0 nthawi.
Ubwino Wake Ndi ChiyaniResveratrol?
Resveratrol yakhala ikufufuzidwa chifukwa cha ubwino wake wathanzi. Zina mwazabwino za resveratrol ndi monga:
1.Kuletsa kukalamba
Mu 2003, pulofesa wa yunivesite ya Harvard David Sinclair ndi gulu lake adapeza kuti resveratrol imatha kuyambitsa acetylase ndikuwonjezera nthawi ya moyo wa yisiti, zomwe zinayambitsa kuwonjezereka kwa kafukufuku wotsutsa ukalamba pa resveratrol. Howitz et al. adapeza kuti resveratrol imatha kukhala ngati choyambitsa champhamvu kwambiri chowongolera zidziwitso zopanda phokoso 2 homolog1 (SIRT1), imatha kutsanzira kuyankha kwa anti-aging of calorie restriction (CR), ndikuchita nawo pakuwongolera nthawi yayitali yamoyo wa zamoyo. . CR ndiyomwe imayambitsa SIRT1 ndipo imatha kukulitsa kufotokozera kwa SIRT1 mu ziwalo ndi minofu monga ubongo, mtima, matumbo, impso, minofu ndi mafuta. CR ingayambitse kusintha kwa thupi komwe kumachedwetsa kukalamba ndikutalikitsa moyo, chofunikira kwambiri chomwe chitha kukulitsidwa ndi 50%. . Kafukufuku watsimikizira kuti resveratrol imatha kukulitsa moyo wa yisiti, nematodes, ntchentche za zipatso ndi nsomba zochepa.
2. Anti-chotupa, anti-cancer
Resveratrol imakhala ndi zoletsa zazikulu pama cell otupa osiyanasiyana monga mbewa hepatocellular carcinoma, khansa ya m'mawere, khansa ya m'matumbo, khansa ya m'mimba, ndi khansa ya m'magazi. Akatswiri ena atsimikizira kuti resveratrol imalepheretsa kwambiri maselo a melanoma kudzera mu njira ya MTT ndi kutuluka kwa cytometry.
Pali malipoti oti resveratrol imatha kukulitsa radiotherapy ya khansa ndikuletsa bwino zotsatira za ma cell stem cell. Koma mpaka pano, chifukwa cha zovuta zamakina odana ndi chotupa a resveratrol, ofufuza sanagwirizanebe pakuchita kwake.
3.Kuteteza ndi kuchiza matenda amtima
Kafukufuku wa Epidemiological apeza kuti chodabwitsa cha "French paradox" ndikuti anthu aku France amadya mafuta ochulukirapo tsiku lililonse, koma zochitika ndi kufa kwa matenda amtima ndizochepa kwambiri kuposa mayiko ena aku Europe. Izi zitha kukhala zokhudzana ndi kumwa kwawo kwa vinyo wambiri tsiku lililonse. , ndipo resveratrol ikhoza kukhala chinthu chake chachikulu chotetezera. Kafukufuku akuwonetsa kuti resveratrol imatha kuwongolera kuchuluka kwa cholesterol m'magazi pomanga ma estrogen receptors m'thupi la munthu, kuletsa mapulateleti kuti asapangitse magazi kuundana komanso kumamatira kumakoma amitsempha yamagazi, potero amalepheretsa ndikuchepetsa zomwe zimachitika komanso kukula kwa matenda amtima, komanso kuchepetsa chiopsezo cha matenda amtima. matenda a mtima m’thupi la munthu. Kuopsa kwa matenda a mitsempha.
4. Chithandizo cha Antioxidant:Resveratrolimagwira ntchito ngati antioxidant, imateteza maselo ku kuwonongeka kwa okosijeni komwe kumachitika chifukwa cha ma free radicals. Izi zitha kukhala ndi zotsatira pazaumoyo komanso ukalamba.
6. Ubongo Wathanzi: Kafukufuku wafufuza ntchito yomwe resveratrol ingakhale nayo pothandizira thanzi laubongo ndi kuzindikira magwiridwe antchito, ndipo maphunziro ena akuwonetsa kuti ali ndi mphamvu zoteteza ubongo.
7.Metabolism ndi Kulemera Kwambiri: Resveratrol yafufuzidwa chifukwa cha zotsatira zake pa kagayidwe kake komanso ntchito yake yothandizira kulemera kwabwino.
Kodi Ma Applications Ndi ChiyaniResveratrol?
Resveratrol ili ndi ntchito zosiyanasiyana ndipo imagwiritsidwa ntchito m'magawo osiyanasiyana chifukwa cha ubwino wake wathanzi. Zina mwazogwiritsa ntchito resveratrol ndi:
1. Zowonjezera Zakudya: Resveratrol imagwiritsidwa ntchito kwambiri pazakudya zowonjezera zakudya, zomwe nthawi zambiri zimagulitsidwa chifukwa cha antioxidant ndi anti-aging properties.
2. Skincare Products: Resveratrol imaphatikizidwa muzinthu zina zosamalira khungu chifukwa cha antioxidant katundu, zomwe zingathandize kuteteza khungu ku kuwonongeka kwa chilengedwe ndikuthandizira thanzi la khungu lonse.
3. Zakudya Zogwira Ntchito ndi Zakumwa: Resveratrol nthawi zina amawonjezeredwa ku zakudya zogwira ntchito ndi zakumwa, monga zakumwa zopatsa mphamvu komanso zakudya zokhudzana ndi thanzi, kuti apereke ubwino wathanzi.
4. Kafukufuku ndi Chitukuko: Resveratrol ikupitirizabe kukhala phunziro la kafukufuku wa sayansi, ndi maphunziro opitirirabe akufufuza momwe angagwiritsire ntchito pazochitika zosiyanasiyana zaumoyo ndi zotsatira zake pa ukalamba, kagayidwe kake, ndi thanzi labwino.
Kodi Pansi pa Resveratrol Ndi Chiyani?
Ngakhale kuti resveratrol yaphunziridwa chifukwa cha ubwino wake wathanzi, ndikofunikira kuganizira zovuta zomwe zingatheke kapena zoperewera zomwe zimagwirizanitsidwa ndi kugwiritsidwa ntchito kwake. Malingaliro ena okhudzana ndi kutsika kwa resveratrol ndi awa:
1. Kuchepa kwa Bioavailability: Resveratrol imakhala ndi bioavailability yochepa, kutanthauza kuti thupi silingathe kuyamwa ndi kuligwiritsa ntchito bwino likatengedwa pakamwa. Izi zingakhudze mphamvu yake popanga zotsatira za thanzi zomwe mukufuna.
2. Kupanda Kuyimilira: Ubwino ndi kuchuluka kwa zowonjezera za resveratrol zimatha kusiyana, ndipo pali kusowa kokhazikika pakupanga zowonjezera izi. Izi zingapangitse kuti zikhale zovuta kwa ogula kudziwa mlingo woyenera ndi khalidwe la mankhwala.
3. Zomwe Zingatheke: Resveratrol ikhoza kuyanjana ndi mankhwala ena kapena matenda. Ndikofunika kukaonana ndi katswiri wa zachipatala musanagwiritse ntchito resveratrol, makamaka ngati mukumwa mankhwala ena kapena muli ndi nkhawa zokhudzana ndi thanzi lanu.
4. Zochepa Zofufuza: Ngakhale kuti kafukufuku wina wasonyeza zotsatira zabwino, kufufuza kwina kumafunika kuti mumvetse bwino zotsatira za nthawi yayitali, mlingo woyenera, ndi zoopsa zomwe zingagwirizane ndi resveratrol supplementation.
Monga momwe zilili ndi zowonjezera zilizonse, ndibwino kuti mugwiritse ntchito resveratrol mosamala komanso motsogozedwa ndi akatswiri azachipatala, makamaka ngati muli ndi nkhawa zokhudzana ndi thanzi kapena mukumwa mankhwala ena.
Mafunso Ena Omwe Mungakonde nawo:
Amene ayenera kupewaresveratrol?
Anthu ena ayenera kusamala kapena kupewa resveratrol, makamaka mu mawonekedwe owonjezera owonjezera. Ndikoyenera kuti magulu otsatirawa afunsane ndi katswiri wazachipatala musanagwiritse ntchito resveratrol:
1. Amayi Oyembekezera kapena Oyamwitsa: Chifukwa cha kafukufuku wochepa wokhudza zotsatira za resveratrol pa nthawi ya mimba ndi yoyamwitsa, ndi bwino kuti amayi oyembekezera kapena oyamwitsa apeze malangizo kwa katswiri wa zaumoyo asanagwiritse ntchito resveratrol zowonjezera.
2. Anthu Omwe Amamwa Mankhwala Ochepetsa Magazi: Resveratrol ikhoza kukhala ndi anticoagulant yofatsa, kotero anthu omwe amamwa mankhwala ochepetsa magazi ayenera kukaonana ndi katswiri wa zachipatala asanagwiritse ntchito resveratrol kuti apewe kuyanjana komwe kungachitike.
3. Omwe Ali ndi Matenda Okhudzidwa ndi Hormone: Resveratrol yaphunziridwa chifukwa cha zotsatira zake pa kayendetsedwe ka mahomoni, kotero anthu omwe ali ndi vuto la mahomoni kapena omwe akulandira mankhwala a mahomoni ayenera kugwiritsa ntchito resveratrol mosamala komanso moyang'aniridwa ndi achipatala.
4. Anthu omwe ali ndi Chiwindi: Kafukufuku wina amasonyeza kuti mlingo waukulu wa resveratrol ukhoza kukhala ndi zotsatira pa chiwindi. Anthu omwe ali ndi vuto la chiwindi kapena omwe amamwa mankhwala omwe amakhudza chiwindi ayenera kugwiritsa ntchito resveratrol mosamala komanso moyang'aniridwa ndi achipatala.
Monga momwe zilili ndi zowonjezera zilizonse, ndikofunikira kukaonana ndi dokotala musanagwiritse ntchito resveratrol, makamaka ngati muli ndi nkhawa zokhudzana ndi thanzi lanu, mukumwa mankhwala, kapena muli ndi vuto linalake.
Kodi resveratrol imachita chiyani pakhungu?
Resveratrol imakhulupirira kuti imapereka zabwino zingapo pakhungu, zomwe zapangitsa kuti aziphatikizidwa muzinthu zosamalira khungu. Zina mwazotsatira za resveratrol pakhungu zingaphatikizepo:
1. Chitetezo cha Antioxidant: Resveratrol imakhala ngati antioxidant, imathandiza kuchepetsa ma radicals aulere komanso kuchepetsa kupsinjika kwa okosijeni pakhungu. Izi zitha kuteteza khungu ku kuwonongeka kwa chilengedwe, monga cheza cha UV ndi kuipitsa.
2. Anti-Aging Properties: Resveratrol imaganiziridwa kuti imakhala ndi zotsatira zotsutsana ndi ukalamba, chifukwa zingathandize kuchepetsa maonekedwe a mizere yabwino ndi makwinya, kusintha khungu, ndikuthandizira thanzi la khungu lonse.
3. Anti-Inflammatory Effects: Resveratrol yaphunziridwa chifukwa cha mphamvu zake zotsutsana ndi kutupa, zomwe zingathandize kuchepetsa ndi kuchepetsa khungu, makamaka kwa anthu omwe ali ndi khungu lodziwika bwino kapena lokhazikika.
4. Kuwala Pakhungu: Kafukufuku wina akusonyeza kuti resveratrol ingathandize kuti khungu likhale lowala komanso madzulo kunja kwa khungu, zomwe zingathe kuchepetsa maonekedwe a hyperpigmentation.
Ndi zakudya ziti zomwe zili ndi resveratrol kwambiri?
Zakudya zomwe zili kwambiri mu resveratrol zikuphatikizapo:
1. Mphesa Yofiira: Resveratrol imakhala yochuluka kwambiri pakhungu la mphesa zofiira, zomwe zimapangitsa vinyo wofiira kukhala gwero la resveratrol. Komabe, ndikofunikira kumwa mowa pang'onopang'ono, ndipo magwero ena a resveratrol atha kukhala abwino kwa osamwa.
2. Mtedza: Mitundu ina ya mtedza, makamaka khungu la mtedza, imakhala ndi resveratrol yambiri.
3. Ma Blueberries: Ma Blueberries amadziwika kuti ali ndi antioxidant, komanso amakhala ndi resveratrol, ngakhale kuti ndi ochepa kwambiri poyerekeza ndi mphesa zofiira ndi mtedza.
4. Cranberries: Cranberries ndi gwero lina la resveratrol, kupereka mlingo wochepa wa mankhwalawa.
5. Chokoleti Chakuda: Mitundu ina ya chokoleti yakuda imakhala ndi resveratrol, yomwe imapereka njira yokoma yophatikizira mankhwalawa muzakudya.
Kodi ndi bwino kumwa resveratrol tsiku lililonse?
Chisankho chotenga resveratrol tsiku lililonse chiyenera kupangidwa pokambirana ndi katswiri wa zachipatala, makamaka ngati akuganiza za resveratrol supplementation. Ngakhale kuti resveratrol nthawi zambiri imawonedwa ngati yotetezeka ikadyedwa muzakudya zomwe zimapezeka nthawi zambiri, chitetezo ndi mapindu a tsiku ndi tsiku a resveratrol supplementation amatha kusiyanasiyana malinga ndi momwe alili, matenda omwe alipo, ndi mankhwala ena omwe amwedwa.
Kodi resveratrol ndi poizoni pachiwindi?
Resveratrol yaphunziridwa chifukwa cha zotsatira zake pa chiwindi, ndipo ngakhale kuti nthawi zambiri imatengedwa kuti ndi yotetezeka ikadyedwa muzakudya zambiri, pali umboni wina wosonyeza kuti mlingo waukulu wa resveratrol ukhoza kukhala ndi zotsatira pa chiwindi. Kafukufuku wina wasonyeza kuti mlingo waukulu wa resveratrol ukhoza kubweretsa chiwopsezo cha chiwindi nthawi zina.
Ndikofunika kuzindikira kuti kafukufuku pamutuwu akupitilira, ndipo kuthekera kwa chiwopsezo cha chiwindi kumatha kutengera kuchuluka kwa mlingo, nthawi yogwiritsira ntchito, komanso thanzi la munthu aliyense. Monga momwe zilili ndi zina zowonjezera, ndi bwino kukaonana ndi katswiri wa zachipatala musanagwiritse ntchito resveratrol, makamaka ngati muli ndi nkhawa zokhudzana ndi thanzi kapena mukumwa mankhwala ena omwe angakhudze chiwindi.
Kodi resveratrol ndi yoyipa kwa impso?
Pali umboni wochepa wosonyeza kuti resveratrol ndi yoyipa kwa impso. Komabe, monga momwe zimakhalira ndi zowonjezera zilizonse, ndikofunikira kuti muzigwiritsa ntchito mosamala, makamaka ngati muli ndi vuto la impso kapena mukumwa mankhwala omwe angakhudze ntchito ya impso. Ndibwino kukaonana ndi katswiri wa zaumoyo kuti muwone ngati resveratrol supplementation ndi yoyenera pa zosowa zanu za umoyo, makamaka ngati muli ndi nkhawa zokhudzana ndi momwe zingakhudzire thanzi la impso.
Zomwe osasakaniza nazoresveratrol?
Mukamaganizira za resveratrol supplementation, ndikofunikira kudziwa momwe mungagwirire ndi zinthu zina. Zina mwazinthu zomwe siziyenera kusakanikirana ndi resveratrol ndi monga:
1. Mankhwala Ochepetsa Magazi: Resveratrol ikhoza kukhala ndi anticoagulant yofatsa, choncho ndikofunika kusamala mukamamwa resveratrol pamodzi ndi mankhwala ochepetsa magazi, chifukwa angapangitse chiopsezo chotaya magazi.
2. Zowonjezera Zina za Antioxidant: Ngakhale kuti ma antioxidants nthawi zambiri amakhala opindulitsa, kumwa mlingo waukulu wa mankhwala ambiri oletsa antioxidant nthawi imodzi kungakhale ndi zotsatira zosayembekezereka. Ndikoyenera kukaonana ndi katswiri wazachipatala musanaphatikize resveratrol ndi mankhwala ena oletsa antioxidant.
3. Mankhwala Ena: Resveratrol ikhoza kuyanjana ndi mankhwala enieni, kuphatikizapo omwe amapangidwa ndi chiwindi. Ndikofunika kukambirana zomwe zingachitike ndi akatswiri azachipatala, makamaka ngati mukumwa mankhwala ena.
Monga chowonjezera china chilichonse, ndikofunikira kufunafuna chitsogozo kuchokera kwa katswiri wazachipatala kuti adziwe momwe angagwiritsire ntchito resveratrol moyenera malinga ndi momwe alili wathanzi komanso momwe angagwiritsire ntchito zinthu zina.
Kodi ndingagwiritse ntchito vitamini C ndi resveratrol?
Inde, mutha kugwiritsa ntchito vitamini C ndi resveratrol. M'malo mwake, kafukufuku wina akuwonetsa kuti kuphatikiza resveratrol ndi vitamini C kungapangitse antioxidant zotsatira zamagulu onsewa. Vitamini C ndi antioxidant yodziwika bwino yomwe imatha kuthandizira phindu la resveratrol. Komabe, monga momwe zimakhalira ndi zoonjezera zilizonse, ndi bwino kukaonana ndi dokotala kuti muwonetsetse kuti kuphatikizako kuli koyenera pazaumoyo wanu komanso kukambirana zomwe zingachitike kapena zomwe mungaganizire.
Nthawi yotumiza: Sep-09-2024
