Tikamakalamba, ntchito ya ziwalo za munthu imawonongeka pang'onopang'ono, zomwe zimagwirizana kwambiri ndi kuchuluka kwa matenda a neurodegenerative. Kusagwira ntchito kwa mitochondrial kumawonedwa kuti ndi chimodzi mwazinthu zofunika kwambiri pakuchita izi. Posachedwapa, gulu lofufuza la Ajay Kumar wochokera ku Indian Institute of Integrated Traditional Chinese and Western Medicine lidafalitsa zotsatira zofunikira pa kafukufuku wa ACS Pharmacology & Translational Science, kuwulula njira yomwecrocetinimachepetsa ukalamba wa ubongo ndi thupi powonjezera mphamvu zama cell.
Mitochondria ndi "mafakitale opangira mphamvu" m'maselo, omwe amapanga mphamvu zambiri zomwe ma cell amafunikira. Ndi ukalamba, kuchepa kwa mapapu, kuchepa kwa magazi m'thupi, ndi kusokonezeka kwa microcirculatory kumabweretsa kuperewera kwa okosijeni ku minofu, kumayambitsa hypoxia yosatha komanso kukulitsa kulephera kwa mitochondrial, potero kumalimbikitsa kufalikira kwa matenda a neurodegenerative. Crocetin ndi mankhwala achilengedwe omwe amatha kupititsa patsogolo ntchito ya mitochondrial. Kafukufukuyu akufuna kufufuza zotsatira za crocetin pa ntchito ya mitochondrial mu mbewa zakale ndi zotsatira zake zotsutsa kukalamba.
●KodiCrocetin?
Crocetin ndi apocarotenoid dicarboxylic acid yachilengedwe yomwe imapezeka mu duwa la crocus pamodzi ndi zipatso zake za glycoside, crocetin, ndi Gardenia jasminoides. Amadziwikanso kuti crocetic acid. [3] [4] Amapanga makhiristo ofiira a njerwa okhala ndi malo osungunuka a 285 ° C.
Kapangidwe kake ka crocetin kumapanga pakati pa crocetin, chigawo chomwe chimapangitsa mtundu wa safironi. Crocetin nthawi zambiri imachokera ku zipatso za gardenia, chifukwa cha kukwera mtengo kwa safironi.
● Motani?CrocetinKukulitsa Mphamvu Zam'ma Cellular ?
Ofufuzawa adagwiritsa ntchito mbewa zakale za C57BL/6J. Makoswe okalamba adagawidwa m'magulu awiri, gulu limodzi linalandira chithandizo cha crocetin kwa miyezi inayi, ndipo gulu lina linatumikira monga gulu lolamulira. Kuzindikira komanso kuyendetsa galimoto kwa mbewa kudawunikidwa ndi kuyesa kwamakhalidwe monga kuyesa kukumbukira malo ndi mayeso otseguka, ndipo njira ya crocetin idawunikidwa ndi maphunziro a pharmacokinetic ndi kutsatizana konse kwa transcriptome. Multivariate regression analysis idagwiritsidwa ntchito kusinthira zinthu zosokoneza monga zaka ndi jenda kuti aunikire zotsatira za crocetin pamalingaliro ndi magwiridwe antchito a mbewa.
Zotsatira zinasonyeza kuti patapita miyezi inayi yacrocetinchithandizo, khalidwe la kukumbukira ndi mphamvu zamagalimoto za mbewa zinasintha kwambiri. Gulu lachipatala lidachita bwino pakuyesa kukumbukira malo, adatenga nthawi yocheperako kuti apeze chakudya, adakhalabe m'manja mwa nyambo nthawi yayitali, ndikuchepetsa nthawi zomwe adalowa m'manja osakhala nyambo molakwika. M'mayesero otseguka, mbewa za gulu la crocetin zinali zogwira ntchito, ndipo zinasuntha mtunda wautali ndi liwiro.
Potsata zolemba zonse za mbewa hippocampus, ofufuza adapeza izicrocetinchithandizo chinayambitsa kusintha kwakukulu m'mawonekedwe a majini, kuphatikizapo kuwonjezereka kwa kufotokozera kwa majini ogwirizana monga BDNF (brain-derived neurotrophic factor).
Maphunziro a pharmacokinetic awonetsa kuti crocetin imakhala yocheperako muubongo ndipo palibe kudzikundikira, zomwe zikuwonetsa kuti ndizotetezeka. crocetin imathandizira bwino ntchito ya mitochondrial ndikuwonjezera mphamvu zama cell mu mbewa zachikulire powonjezera kufalikira kwa okosijeni. Kuchita bwino kwa mitochondrial kumathandiza kuchepetsa ukalamba wa ubongo ndi thupi ndikutalikitsa moyo wa mbewa.
Kafukufukuyu akusonyeza zimenezocrocetinimatha kuchedwetsa kwambiri kukalamba kwaubongo ndi thupi ndikukulitsa moyo wa mbewa okalamba mwa kukonza magwiridwe antchito a mitochondrial ndikuwonjezera mphamvu zama cell. Malingaliro enieni ndi awa:
Wonjezerani crocetin moyenera: Kwa okalamba, kuwonjezera crocetin pang'onopang'ono kungathandize kupititsa patsogolo luso la kuzindikira ndi kuyendetsa galimoto ndikuchedwetsa ukalamba.
Kusamalira thanzi labwino: Kuphatikiza pa kuwonjezera crocetin, muyenera kukhala ndi zakudya zopatsa thanzi, kuchita masewera olimbitsa thupi nthawi zonse komanso kugona bwino kuti mukhale ndi thanzi labwino.
Samalani chitetezo: Ngakhalecrocetinzikuwonetsa chitetezo chabwino, muyenerabe kulabadira mlingo mukamawonjezera ndikuchita motsogozedwa ndi dokotala kapena kadyedwe.
● NEWGREEN Supply Crocetin /Crocin /Saffron Extract
Nthawi yotumiza: Oct-23-2024
