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Ntchito:

1. Amawongolera matenda a m'mimba

Zinapezeka kuti zotsatira za polysaccharide pa matenda a m'mimba zimawonekera makamaka m'zinthu zitatu zotsatirazi: (1) Polysaccharide inali ndi zotsatira zochotsa Helicobacter pylori, kulepheretsa kufalikira kwa Helicobacter pylori ndikuletsa kumangiriza kwake ndi m'mimba mucosa; (2) Lili ndi zotsatira zoteteza chapamimba mucosa ndi kuchiza chapamimba chilonda, ndipo ali ndi zotsatira zabwino zochepetsera mowa ndi mankhwala ochititsa chapamimba mucosal kuvulala ndi aakulu chapamimba chilonda; (3) Fucoidan ali ndi zotsatira zotsutsana ndi khansa ya m'mimba, amatha kulepheretsa kuchuluka kwa maselo a khansa ya m'mimba, kuchepetsa zotsatira za mankhwala a chemotherapy, komanso kusintha moyo wa odwala.

2. Anticoagulant zotsatira

Fucoidan ili ndi ntchito zambiri zachilengedwe, koma anticoagulant yake ndiyomwe imaphunziridwa kwambiri. Kafukufuku wasonyeza kuti ma polysaccharides otengedwa kuchokera ku ndere zofiirira za Marine ali ndi magawo osiyanasiyana a anticoagulant. Mwachitsanzo, polysaccharides kuchokera ndipo anasonyeza mkulu mlingo wa anticoagulant ntchito, ndi anticoagulant ntchito ndipo anali theka la woyamba, koma pafupifupi palibe anticoagulant ntchito.

3. Antithrombotic zotsatira

M'chitsanzo choyesera cha nyama zamoyo, polysaccharide ya fucoidan imakhala ndi zotsatira zoletsa pa venous thrombosis ndi arterial thrombosis. Rocha et al. anapeza kuti polysaccharide analibe anticoagulant ntchito mu m`galasi, koma anasonyeza zoonekeratu antithrombotic mmene nyama chitsanzo kupanga venous thrombosis, ndipo zotsatira anali nthawi amadalira, kufika pazipita pambuyo 8h makonzedwe. Ntchito ya anticoagulant ya polysaccharide mwina inali yokhudzana ndi kulimbikitsa kupanga kwa heparin sulfate ndi maselo a endothelial.

4. Antiviral zotsatira

Kafukufuku wawonetsa kuti ma polysaccharides a sulfated (kuphatikiza ma fucoidan polysaccharides) amawonetsa antivayirasi mu vivo komanso mu vitro. Hayashi et al. adaphunzira zachitetezo cha fucoidan pa herpes simplex virus (HSV). Iwo adapeza kuti fucoidan imatha kuteteza mbewa ku matenda a HSV, ndipo adanenanso kuti fucoidan imatha kuteteza matenda a HSV poletsa kubwereza kwa kachilomboka ndikuwonjezera chitetezo cham'mimba komanso chopeza chitetezo. Nthawi yomweyo, zidapezekanso kuti polysaccharide iwonetsa antiviral ntchito motsutsana ndi HSV-1 ndi HSV-2. Hidari et al. adanenanso kuti fucoidan imatha kuletsa bwino matenda a dengue virus mtundu wa 2 (DEN2), ndipo idawonetsa kuti fucoidan imamangiriza ku tinthu tating'ono ta DEN2 ndikulumikizana ndi ma CD ake a glycoprotein. Zilibe mwachindunji passivation zotsatira pa virions, ndi sapha mavairasi oyambitsa limagwirira ndi ziletsa mapangidwe HIV cytiocytes ndi inhibiting adsorption wa HIV.

5. Anti-chotupa zotsatira

Fucoidan imawonedwa ngati mankhwala achilengedwe odana ndi khansa, ndipo ntchito yake yolimbana ndi chotupa yanenedwa mochulukira. Alekseyenko et al. adaphunzira ntchito yolimbana ndi chotupa cha fucoidan pa mbewa zomwe zimadwala Lewis lung adenocarcinoma, ndikudyetsa fucoidan pa mlingo wa 10mg/kg kwa mbewa, zomwe zimapangitsa kuti pakhale ntchito yolimbana ndi chotupa komanso anti-chotupa metastasis effect. Kafukufuku wina adapezanso kuti chotupa choletsa kuchuluka kwa fucoidan pa nyama 5 zomwe zili ndi S180 sarcoma zinali 30%, ndipo sarcoma ya nyama ziwiri idatha. Mu mbale ya petri yokhala ndi pafupifupi 10,000 maselo a khansa ya m'matumbo omwe amathandizidwa ndi algae polysaccharides achilengedwe omwe amapezeka ku kelp, 50 peresenti ya maselo a khansa adamwalira patatha maola 24, ndipo pafupifupi maselo onse a khansa adamwalira patatha maola 72. Hyun et al. anapeza kuti polysaccharide ya mwala algae akhoza kwambiri ziletsa kukula kwa HCT-15 m'matumbo khansa maselo. Pambuyo pochiza HCT-15 cell line ndi rock algae polysaccharide, zochitika za apoptotic monga kusweka kwa DNA, kuphatikizika kwa chromosome, ndi kuchuluka kwa ma cell a subdiploid mu gawo la G1.

6. Antioxidant zotsatira

Kuyesa kwakukulu kwa in vitro kwawonetsa kuti polysaccharide ya mwala algae imakhala ndi antioxidant ntchito, ndi mtundu wa antioxidant wachilengedwe, ndipo imatha kuteteza bwino matendawa omwe amayamba chifukwa cha ma free radicals. Costa et al. adatulutsa ma polysaccharides a sulfated kuchokera ku mitundu ya 11 yamadzi am'madzi otentha, onse omwe anali ndi antioxidant ntchito, amatha kupanga chelates yachitsulo ndi kuchepetsa mphamvu, 5 yomwe inali ndi mphamvu yochotsa ma hydroxyl radicals, ndipo 6 yomwe inali ndi mphamvu yochotsa peroxy radicals. Micheline et al. adanenanso kuti ma polysaccharides ochokera ku algae amatha kuletsa mapangidwe a hydroxyl radical and superoxide radical.

7. Ntchito ya chitetezo cha mthupi

Fucoidan ili ndi ntchito zambiri zoteteza thupi, kuphatikizapo anti-complement action, anti-inflammatory response and immunomodulatory effects. Tissot et al. adatsimikizira kuti polysaccharide ya fucoite imatha kuletsa mapuloteni othandizira mu seramu yabwinobwino yamunthu, motero kuletsa kusungunuka kwa maselo ofiira amagazi a nkhosa chifukwa cha kuyambitsa kowonjezera, ndikuletsa kuyambitsa kowonjezera poletsa gawo loyamba la njira yoyambira yoyambira (kuphatikiza. chigawo choyamba chowonjezera, chachiwiri ndi chachinayi). Yang ndi al. adapeza kuti fucoidan imatha kuletsa mwadala kufotokoza kwa inducible nitric oxide synthase m'maselo otupa ndipo imakhala ndi anti-yotupa. Mizuno et al. amagwiritsa ntchito co-culture dongosolo la m'mimba epithelial Caco-2 maselo ndi macrophage RAW264.7 kuwunika odana ndi yotupa zotsatira za chakudya zinthu, ndipo zotsatira anasonyeza kuti polysaccharide wa S. japonicum akhoza kulimbikitsa kupanga chotupa necrosis factor.α mu RAW264.7, potero amalepheretsa mawu a mRNA a interleukin m'maselo a Caco-2.

8. Kupititsa patsogolo umuna

Kuwongolera kwa fucoidan kumatha kupititsa patsogolo umuna ndi kuchuluka kwa umuna mwa kukonza ma metabolites amagazi ndi ma microbiota am'mimba. Ofufuzawa adapeza kuti atapatsidwa ma polysaccharides am'madzi am'madzi, kuchuluka kwa ma jini okhudzana ndi spermatogenesis adawonjezeka kwambiri m'mayesero a mbewa. Panthawi imodzimodziyo, panali mgwirizano wabwino pakati pa matumbo a microbiota ndi ma metabolites a magazi. Poyang'anira ziwirizi, polysaccharide ya fucoite imathandizira ma metabolites a testis, kuchulukitsa chitetezo cha antioxidant, ndikuwongolera kuchuluka kwa ma jini okhudzana ndi ma cell a majeremusi, motero kumathandizira kuti umuna ukhale wabwino.