Kuyera Kwambiri Metformin CAS 657-24-9 Wopanga Metformin
Mafotokozedwe Akatundu
Metformin: Mankhwala amphamvu ochizira matenda a shuga
1. Kodi metformin ndi chiyani?
Biguanides amapezeka mu udzu wa mbuzi ( Galega Officinalis ), chomera chomwe chakhala chikugwiritsidwa ntchito mu mankhwala amtundu kwa zaka mazana ambiri. Zochita za pharmacological za mbewuyo zimatengera mbuzi (Isoamylene guanidine). Phenformin, Buformin, ndi metformin onse amapangidwa ndi mankhwala ndipo amakhala ndi mamolekyu awiri a guanidine. Metformin ndi mankhwala amkamwa omwe amagwiritsidwa ntchito kwambiri pochiza matenda amtundu wa 2. Ndiwo gulu la mankhwala otchedwa biguanides ndipo amatengedwa ngati chithandizo choyambirira cha matenda a shuga.
2. Kodi metformin imagwira ntchito bwanji?
Ntchito yayikulu ya Metformin ndikuchepetsa kuchuluka kwa shuga wopangidwa ndi chiwindi ndikupangitsa kuti maselo amthupi azitha kumva bwino ndi insulin. Imatsitsa shuga m'magazi ndikuwongolera momwe thupi limayankhira insulin.
Metformin imayang'anira shuga m'magazi makamaka poletsa kutuluka kwa shuga m'chiwindi. Metformin makamaka amadalira organic cationic transporter 1 (OCT 1) kulowa mu hepatocytes, ndiyeno pang'ono amalepheretsa mitochondrial kupuma unyolo zovuta 1, kuchititsa kuchepa kwa intracellular ATP ndi kuchuluka kwa AMP milingo. Tonse tikudziwa kuti kuchepa kwa ATP ndi kuwonjezeka kwa AMP mu selo kudzalepheretsa mwachindunji gluconeogenesis ndikuchepetsa kutembenuka kwa glycerol kukhala shuga.
Kuwonjezeka kwa AMP/ATP chifukwa cha metformin kumayambitsanso njira yowonetsera ya AMPK, yomwe imalepheretsa kaphatikizidwe ka mafuta ndikuwonjezera chidwi cha thupi ku insulin.
3. Ubwino wa metformin ndi chiyani?
Metformin imapereka maubwino angapo kwa odwala matenda ashuga: +
1) Kuwongolera shuga m'magazi: Pochepetsa kupanga shuga m'chiwindi ndikuwongolera chidwi cha insulin, metformin imathandizira kuwongolera kuchuluka kwa shuga m'magazi ndikuletsa kukwera kapena kutsika kwambiri.
2) Kuwongolera kulemera: Metformin nthawi zambiri imapangitsa kuti anthu omwe ali ndi matenda a shuga achepetse thupi. Imachita izi pochepetsa kulakalaka kudya, kukulitsa kukhuta, komanso kuthandizira kulowa m'malo osungira mafuta kuti apeze mphamvu.
3) Chitetezo cha Mtima: Kafukufuku amasonyeza kuti metformin ikhoza kuchepetsa chiopsezo cha matenda a mtima, monga matenda a mtima ndi sitiroko, mwa anthu omwe ali ndi matenda a shuga.
4) Polycystic ovary syndrome (PCOS): Kuphatikiza pa kuchiza matenda a shuga, metformin imagwiritsidwa ntchito pochiza PCOS, matenda a mahomoni omwe amakhudza amayi. Amathandizira kuwongolera msambo, amachepetsa kukana kwa insulini, komanso amathandizira kubereka.
4.Kodi metformin ingagwiritsidwe ntchito kuti?
Metformin imagwiritsidwa ntchito kwambiri pochiza matenda amtundu wa 2. Itha kugwiritsidwa ntchito yokha kapena kuphatikiza ndi mankhwala ena amkamwa a antidiabetic kapena kuphatikiza ndi insulin, kutengera zosowa za munthu. Metformin imasonyezedwa kuti igwiritsidwe ntchito mwa anthu omwe angopezeka kumene komanso mwa anthu omwe amawongolera matenda a shuga kwa nthawi yayitali. Mwachidule, metformin ndi mankhwala amphamvu omwe amagwiritsidwa ntchito kwambiri pochiza matenda amtundu wa 2 ndi PCOS. Ili ndi maubwino monga kuwongolera shuga wamagazi, kuwongolera kulemera, chitetezo chamtima, komanso mpumulo wazizindikiro za PCOS. Chifukwa chakuchita bwino komanso kugwiritsidwa ntchito kofala, metformin yakhala chida chofunikira pothandizira anthu kukhala ndi moyo wathanzi ndikuwongolera bwino matenda awo.
Chakudya
Kuyera
Makapisozi
Kumanga Minofu
Zakudya Zowonjezera
Mbiri Yakampani
Newgreen ndi bizinesi yotsogola pazakudya zowonjezera chakudya, yomwe idakhazikitsidwa mu 1996, yomwe ili ndi zaka 23 zakutumiza kunja. Ndi luso lake lopanga kalasi yoyamba komanso msonkhano wodziyimira pawokha, kampaniyo yathandizira chitukuko cha zachuma m'maiko ambiri. Masiku ano, Newgreen imanyadira kuwonetsa zatsopano zake - mitundu yatsopano yazakudya zomwe zimagwiritsa ntchito ukadaulo wapamwamba kupititsa patsogolo chakudya.
Ku Newgreen, ukadaulo ndiyemwe umayambitsa chilichonse chomwe timachita. Gulu lathu la akatswiri likugwira ntchito mosalekeza popanga zinthu zatsopano komanso zowongoleredwa kuti zipititse patsogolo zakudya zabwino ndikusunga chitetezo ndi thanzi. Tikukhulupirira kuti luso lamakono lingatithandize kuthana ndi zovuta za dziko lofulumira komanso kusintha moyo wa anthu padziko lonse lapansi. Zowonjezera zatsopano zimatsimikiziridwa kuti zikwaniritse miyezo yapamwamba yapadziko lonse, kupatsa makasitomala mtendere wamaganizo.Timayesetsa kumanga bizinesi yokhazikika komanso yopindulitsa yomwe sikuti imangobweretsa chitukuko kwa antchito athu ndi eni ake, komanso imathandizira kuti dziko likhale labwino kwa onse.
Newgreen imanyadira kuwonetsa zatsopano zaukadaulo wapamwamba kwambiri - mzere watsopano wazowonjezera pazakudya zomwe zipangitsa kuti chakudya chikhale chabwino padziko lonse lapansi. Kampaniyo yakhala ikudzipereka kwatsopano, kukhulupirika, kupambana-kupambana, ndi kutumikira thanzi laumunthu, ndipo ndi bwenzi lodalirika pazakudya. Poyang'ana zam'tsogolo, ndife okondwa ndi mwayi waukadaulo ndipo tikukhulupirira kuti gulu lathu lodzipereka la akatswiri lipitiliza kupatsa makasitomala athu zinthu ndi ntchito zapamwamba kwambiri.
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